蘭州大學生命科學學院導師介紹：彭雅麗

導師信息來源：中國考研網 2015-07-22　相關院校：蘭州大學

學習經歷

1996.9－2000.6，蘭州大學生物化學專業，學士
2001.9－2006.6，蘭州大學生物化學專業，碩博連讀，導師：王銳
工作經歷 2000.8-2001.7，甘肅榆中恩玲中學，教師，研究生支教工作
2006.7-2011.4，蘭州大學生命科學學院，講師
2011.5-至今，蘭州大學生命科學學院，副教授

教學及指導研究生情況

承擔本科生《分子生物學》、《生物技術制藥》課程。

碩士生導師。

發表論文及專著

Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Han RW, Chang M*, Wang R*. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 doi:10.1016/j.nlm.2015.05.010 (SCI)
Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M*, Wang R*. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48. (SCI)
Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem. 2014 ;107:32-6. (SCI)
Han, RW, Zhang RS, Xu HJ, Chang M, Peng YL, Wang R*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Abeta42 in mice novel object and object location recognition tasks, Neuropharmacology, 2013;70:261-7.(SCI)
Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R*, Han YF. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Res. 2012;1470:59-68. (SCI)
Peng YL, Zhang JN, Chang M, Li W, Han RW, Wang R*. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-83. (SCI)
Peng YL, Han RW, Chang M, Zhang L, Zhang RS, Li W, Han YF, Wang R*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-63. (SCI)
Chang M, Li W, Peng YL, Gao YH, Yao J, Han RW, Wang R*. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6]γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Res. 2009;1271:36-48. (SCI)
Li W, Chang M, Peng YL, Gao YH, Zhang JN, Han RW, Wang R*. Neuropeptide S produces antinociceptive effect at the supraspinal level in mice. Regul. Pept. 2009;156:90-5. (SCI)
Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009;30(7): 1313-17. (SCI)
Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment in mice morris water maze. Neuro. Lett. 2009;455:74-7. (SCI)
Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R*. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides. 2009;30(2):234-40. (SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Regulation of Endochondral Ossification by Osteogenic Growth Peptide C-terminal Pentapeptide [OGP(10-14)]. Protein Pept. Lett. 2009;16:1074-80. (SCI)
常民, 彭雅麗, 李威, 王銳. 神經肽S的功能與構效關系研究進展. 生物物理學報. 2009;03:175-82.
Li Z, Zhou LX, Zhang BH, Yan X, Li J, Peng YL, Chang M, Dong SL, Wang R*. Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell.Pharmazie. 2008;63(9):676-85.(SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept. 2007;142(1-2):16-23. (SCI)
Peng YL, Chang M, Dong SL, Li W, Han RW, Fu GX, Chen Q, Wang R*. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4, Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regul. Pept. 2006;134:75-81. (SCI)
Fang Q, Guo J, Peng YL, Chang M, He F, Chen Q, Wang R*. In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors. Peptides. 2006;27:1297-304. (SCI)
Yang Q, Chen Y, Fu C, Chang M, Peng YL, Wang R*. Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.Protein Pept Lett. 2006;13(2):185-8.(SCI)

專利：

一種固液相縮合制備胸腺肽α1的方法，申請號：CN201310523706.1；
液相片段縮合制備胸腺肽α1的方法，申請號：CN201310523577.6；
片段縮合制備醋酸鮭魚降鈣素的方法，申請號: CN201410420967.5;
片段縮合制備特利加壓素的方法，申請號: CN201410554759.4
一種片段縮合制備曲普瑞林的方法，申請號: CN201410743707.1
一種片段縮合制備醋酸去氨加壓素的方法，申請號: CN201410748612.9
一種片段縮合制備醋酸阿托西班的方法，申請號: CN201410802681.3
片段縮合制備利拉魯肽的方法，申請號：CN201510079168.0

研究方向

1、神經肽

2、多肽合成

3、多肽藥理學

項目成果

主持項目：

1、神經肽S與疼痛下行抑制通路關系的研究（30900445）。國家自然科學基金委。

2、一種治療阿爾茨海默病的新多肽藥物的設計和活性研究（0708NKCA111）。甘肅省科技廳。

3、新的胸腺肽α1生產工藝的研究（07-3-08）。蘭州市科技局。

參與項目：

1、若干多肽合成和化學修飾的新方法研究及其在多肽藥物產業開發中的應用（2009ZX09503）。科技部“重大新藥創制”科技重大專項。