蘭州大學基礎醫學院導師介紹：張小郁

導師信息來源：中國考研網 2015-07-28　相關院校：蘭州大學

姓名: 張小郁
Name: Zhang Xiaoyu
職稱：教授，碩士生導師
Duty: Professor
E-mail：zhangxyu@lzu.edu.cn

科研方向

1、采用規范的細胞和分子生物學/生理學技術進行有關生理、藥理學方面的研究。
2、采用細胞信號轉導、氧化脅迫以及細胞凋亡技術對心血管疾病、糖尿病以及肥胖等進行研究。
Research Interests：
1. Work with a major responsibility of physiology and pharmacology using standard cellular and molecular biology/physiology techniques.
2. Focus on cell signaling, oxidative stress, and apoptosis in a number of cardiovascular diseases, diabetes, and obesity.

榮譽稱號及獎勵：

1. 2004年甘肅省醫療衛生中青年學術技術帶頭人。
2. 《葡萄籽中原花青素對阿霉素增效減毒作用及機理研究》榮獲2006年甘肅省自然科學二等獎（1/5），甘肅省高校科技進步一等獎（1/8），蘭州大學優秀博士論文。
3. 2007年榮獲蘭州大學度首屆“隆基中青年教師教學骨干獎”，獲得國家留學基金委資助作為訪問學者去美國進行科學研究一年，提高科研水平。
4. 2011年，第十一屆全國多媒體課件大賽決賽三等獎（第三完成人）
5. 2007年，《生理學立體教學模式的探索——依托精品課程推動教學創新》蘭州大學教學成果二等獎（第四完成人）
Honors and awards：
1. In 2004, I won the Discipline Leader on Young and Middle-aged Science and Technology of Public Health Department of Gansu.
2. In 2006, Mechanisms of Proanthocyanidin from Grape Seeds in both Potentiating Anti-tumor Activity and Reducing Toxicity of Doxorubicin obtained the second prize of Gansu Provincial Natural Science, the first prize of scientific and techonology progress in Gansu Provincial advanced colleges and was entitled as the Excellence Doctor Paper in Lanzhou University. (first author).
3. In 2007, I won the prize of the Longji Excellence Teacher in Lanzhou University. At the same time, I got through the academic selection process organized by China Scholarship Council (CSC) and was granted the funds to study abroad for a year.

個人簡歷

張小郁，女，博士，碩士生導師，蘭州大學基礎醫學院醫學生理學研究所教授，學科帶頭人，甘肅省醫療衛生中青年學術技術帶頭人，留美訪問學者。中國生理學會消化內分泌生殖代謝生理專業委員會委員，甘肅省生理學會理事。
2008年12月至2009年11月在美國University of Wyoming和The State University of Newyork at Buffalo做訪問學者期間，利用分子生物學等先進技術熟練掌握了心肌缺血再灌注損傷保護作用的世界前沿研究技術，發表相關SCI論文3篇；并對ISL抗腫瘤作用的分子機制進行了系統研究，論文<Natural antioxidant-Isoliquiritigenin selectively inhibits growth of prostate cancer cells>已于2010年發表在SCI刊物Clin Exp Physiol Pharm上。2006年獲甘肅省自然科學進步二等獎1項，發表科研論文30余篇，其中SCI收錄10余篇。完成甘肅省自然科學和蘭州市科技項目基金項目各一項。目前主持一項甘肅省自然科學基金項目。本項目作為負責人，全面負責課題的組織、管理和實施，負責實驗設計、數據整理和分析、論文撰寫，指導模型制作和分子生物學檢測。
1. 1983年9月至1998年7月在原蘭州醫學院臨床醫學系攻讀本科。
2. 1996年9月至1999年7月在原蘭州醫學院藥理學攻讀碩士。
3. 2002年9月至2005年6月在蘭大生命科學學院動物生理學攻讀博士。

工作經歷

1. 1998年9月至1996年7月在蘭拖廠醫院任主治醫師。
2. 1999年7月至2000年6月在原蘭州醫學院生理學教研室任助教。
3. 2000年7月至2002年6月在原蘭州醫學院生理學教研室任講師。
4. 2002年7月至2004年11月在原蘭州醫學院生理學教研室任副教授。
5. 2004年11月至2008年5月在蘭州大學基礎醫學院生理學研究所任副教授。
6. 2008年5月---至今在蘭州大學基礎醫學院生理學研究所任教授。
7. 2008年12月至2009年12月在美國懷俄明大學做訪問學者。

Resume
1. Sept. 2002--- June 2005Ph.D. in Physiology, the Life Science School of Lanzhou University, Lanzhou 730000, Gansu, P.R.China.
2. Sept. 1996--- June 1999M.S. in Pharmacology, the Department of Pharmacology of Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China.
3. Sept. 1983---July 1988   B.S. in Clinical Medicine, the Department of Clinical Medicine of Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China.
Working Experiences
1. Dec. 2008--- Dec. 2008   visiting scholar in University of Wyoming, USA
2. May 2008---NowProfessor, Institute of Physiology，School of Basic Medicine Science, Lanzhou University, Lanzhou 730000, Gansu, P.R.China
3. Nov. 2004--- May 2008Associate Professor, Institute of Physiology，School of Basic Medicine Science, Lanzhou University, Lanzhou 730000, Gansu, P.R.China
4. July 2002--- Nov. 2004Associate Professor, Department of Physiology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China
5、Oct. 2000---July 2002Lecturer, Department of Physiology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China
6. July 1999---Oct. 2000   Assistant，Department of Physiology, Lanzhou Medical College, Lanzhou 730000, Gansu, P.R.China
7. Sept. 1988--- July 1996   Attending physician, Hospital of Lanzhou Tractor Factory, Lanzhou 730050, Gansu, P.R.China

主持的科研項目：

1. 主持甘肅省省自然科學研究基金計劃項目一項（1208RJZA231），異甘草素抗腫瘤血管生成的機制研究，2012.1-2014.12
2. 主持甘肅省省自然科學研究基金計劃項目一項（0710RJZA037），稀土配合物抗腫瘤作用分子機理研究，2008.1-2009.12
3. 主持蘭州市科技計劃資助項目一項（1208RJZA231）異甘草素抗腫瘤血管生成的機制研究，2007.1-2008.12
4. 主持企事業單位委托項目，戊肝疫苗臨床前重復給藥，毒性試驗，2005.11-2007.6
5. 主持企事業單位委托項目，蛇葡萄素抗腫瘤作用的研究，2006.4-2007.12
6. 主持蘭州大學醫學基金一項，稀土配合物抗腫瘤作用及機理研究，2007.1-2008.12
7. 主持甘肅省新藥臨床前研究重點實驗室開放課題基金一項，二（2-吡啶基-N-氧化物）二硫化物鑭稀土配合物的抗腫瘤作用及機理研究，2006.1-2008.12
參與科研項目情況：
1. 以項目組主要成員（2/9）參與國家自然科學基金委——面上項目一項，填充吸附微量萃取法結合細胞代謝組學研究金納米材料的毒性，2014.1-2017.12
2. 以項目組主要成員（2/4）參與甘肅省自然基金項目一項，抗病毒藥篩選模型的建立及抗病毒中藥，2004.7-2006.12

發表論文

Publications
1. Xiaoyu Zhang, Ping Zhu, Xiuying Zhang, Yina Ma, Wenguang Li, Ji-Mei Chen,Hui-Ming Guo, Richard Bucala, Jian Zhuang, and Ji Li. Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway. Mediators of Inflammation. Volume 2013, Article ID 390890, 10 pages.(SCI, IF2013 = 3.882)
2. XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247–1257. (SCI)
3. XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309–318. (SCI)
4. XiaoYu ZHANG, WenGuang LI, YongJie WU and MingTang GAO. Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice. J. Pharmacy Pharmacol. 2005: 57(8): 1043–1052. (SCI)
5. Xiaoyu ZHANG, Decheng BAI, Yongjie WU, Wenguang LI and Naifa LIU. Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533–538. (SCI)
6. XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432–438. (SCI)
7. Xiaoyu Zhang, Jingying Wang, Wenguang Li, Ji Li. Natural Antioxidant-Isoliquiritigenin Protects Heart against Ischemia-Reperfusion Injury via Activation of Cardioprotective Signaling Pathways. Circulation. 2009;120:S1445.(Abstract) (SCI)
8. Xiaoyu Zhang, Eddie D Yeung, Jingying Wang, Evgeniy E Panzhinskiy, Tong Chao, Wenguang Li, Ji Li. Natural antioxidant-Isoliquiritigenin selectively inhibits growth of prostate cancer cells. Clin. Exp. Physiol. Pharm. 2010; 37: 841–847 (SCI)
9. WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG.. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941–949. (SCI)
10.LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 2002; 23(8): 727–732. (SCI)
11.LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI)
12.ZHANG XiaoYu, ZHENG TianZhen and PANG JinJiang. Effects of progesterone on contractile activity of trachea smooth muscle in rabbits. Chin J Appl Physiol. 2003; 19(4): 388, 401. (CSCD)
13.ZHANG XiaoYu, LI WenGuang, ZHENG TianZhen and LI　Ｗei. Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals. Chin J Appl Physiol. 2005; 21(4): 383-386. (CSCD)
14.ZHANG XiaoYu, LI WenGuang, GAO MingTang and TIAN Xuan. Protectective effect on injured myocardial cells of proanthocyanidins in vitro. Pharmacol Clin Chin Materia Med. 2001; 17(6): 14-16 (CSCD)
15.ZHANG XiaoYu, GAO MingTang, LI WenGuang, TIAN Xuan and ZHU JuHua. The anti-lipoperoxidative effect of grape seed extract in vitro. Advanced in Free Badical Life Sciences. 1999; 7: 116-120.
16.ZHANG XiaoYu, ZHANG YongPing and LI WenGuang. Anti-tumor activity of lanthanum nitrate Complexes with bis(2-pyridyl-N-Oxide)disulphide in vitro. J Lanzhou University ( Natural Sci). 2004; 40Supp: 34–36. (CSCD)
17.ZHANG XiaoYu, LI WenGuang, WU YongJie and GAO MingTang. CHL chromosome aberration test of proanthocyanidinsfrom grape seeds. J Lanzhou University ( Natural Sci). 2002; 38(6) Supp: 15-17. (CSCD)
18.Xiaoyu Zhang, Jingying Wang, Wenguang Li, Ji Li. Natural Antioxidant-Isoliquiritigenin Protects Heart against Ischemia-Reperfusion Injury via Activation of Cardioprotective Signaling Pathways. Circulation. 2009;120:S1445.(Abstract)
19.Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008；60(2): 179-188. (SCI)
20.Zheng-lan Han, Zi-long Wang, Hong-zhu Tang, Ning Li, Quan Fang*, Xu-hui Li, Xiong-li Yang, Xiao-yu Zhang, Rui Wang* .Neuropeptide FF attenuates the acquisition and the expression of conditioned place aversion to endomorphin-2 in mice. Behav Brain Res. 2013; 248; 51-56. (SCI)
21.SI JinChao, ZHANG XiaoYu, LIN MeiLing, DING YongHui, LI Mei, QU SongYi and ZHENG TianZhen. Effects of Ephedra on body mass, serum lipid, glucose and hormone level of ovarietomized obese rats. Chin J Clin Rehabilit. 2006; 10(47): 209–212. (CSCD)
22.LI WenGuang, ZHANG XiaoYu and WU YongJie. Effect of podophyllic acid hydrozide piperidingyloxy and its derivatives on MDA formation. Chin Pharmacol Bull. 1997; 13(5): 422-424. (CSCD)
23.Jingying Wang, Heng Ma, Xiaoyu Zhang, Leilei He, Jianming Wu, Xiaoping Gao, Jun Ren, Ji Li. A Novel AMPK Activator from Chinese Herb Medicine and Ischemia Phosphorylate the Cardiac Transcription Factor FOXO3. Int J Physiol Pathophysiol Physiol. 2009: 1: 116-126 (SCI)
24.Peng Zhao, Jingying Wang, Leilei He, Heng M, Xiaoyu Zhang, Xinglei Zhu, E. Kurt Dolence, Jun Ren, Ji Li. Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia. J. Cell. Mol. Med. 2009; 13: 1513–1525 (SCI)
25.Wang Jun, Wang Hao, Guo Zhen, ZHANG XiaoYu, QU SongYi and ZHENG TianZhen. Gastrodin in modulating body mass and metabilism in obese rats fed with high-fat diet. J Clin Rehabilit. Tissue Engineering Res. 2008; 12(207): 3992–3996. (CSCD)
26.Guo Jiaohong, Li Xujun, Yue Jia, ZHANG XiaoYu, Lin Meiling and ZHENG TianZhen. The effects of Radix Achykanthis Bidentatae from Henan of China on body weight and tumor Necrosis Factor-α in ovariectomized obese rats. J Chengdu Medical College 2008; 3(2): 100–102, 106.
27.Li Xujun, Yue Jia, Chang Yanqin, Lin Meiling, ZHANG XiaoYu, Ding Yonghui and ZHENG TianZhen. Effects of Rhizoma Wenyujin Concisum on ovariectomized obese rats. China J Modern Med. 2008; 18(4): 405–407, 412. (CSCD)
28.袁良杰，盧霞，王君，鄭天珍，瞿頌義，張小郁*. 苦參堿對高脂肥胖大鼠體重、血脂和抗過氧化能力的影響. 時珍國醫國藥. 2008; 19（9）: 2062-2064（*為通訊作者）(CSCD)
29.白巖，盧伍黨，李文廣，張小郁*. 金屬配合物Cu(Ⅱ)1-羥基-3-（2-環氧基）噸酮的體外抗腫瘤作用. 蘭州大學學報（醫學版）. 2010; 36(2): 56-60 （*為通訊作者）
30.白巖，盧伍黨，李文廣，張小郁*. 金屬配合物Cu(Ⅱ)噸酮冠醚的體外抗腫瘤作用. 蘭州大學學報（醫學版）. 2010; 36(3): 21-25（*為通訊作者）
31.黃征，張林，瞿頌義，鄭天珍，張小郁*. 天麻素對大鼠離體脂肪組織釋放游離脂肪酸及抗氧化作用的影響. 第四軍醫大學學報(J. Fourth Mil. Univ.). 2009：30（16）：1488-1490. （*為通訊作者）(CSCD)
32.朱家恩，白延斌，藺美玲，鄭天珍，瞿頌義，丁永輝，張小郁*.白芍對去卵巢大鼠體重、血脂及抗氧化能力的影響.中國老年學雜志，2009, 29(2): 135-137 （*為通訊作者）(CSCD)
33.趙麗，陳紅梅，藺美玲，劉世雄，李中平，王志強，張小郁*，鄭天珍.原花青素對STZ致胰島細胞損傷的保護作用. 中國老年學雜志，2011, 31(23): 4580-4582 （*為通訊作者）(CSCD)
34.李中平，任文輝，張寶麗，藺美玲，陳紅梅，趙麗，王志強，張小郁*.檳榔堿對STZ致INS-1細胞損傷的保護和修復作用. 中國老年學雜志，2011, 31(23): 4583-4585 （*為通訊作者）(CSCD)
35.王志強，黃雙盛，劉圓圓，胡臘梅，李文廣，侯翠蘭, 張小郁*。異甘草素的抗腫瘤血管生成作用.中國科技論文在線, 2012（*為通訊作者）

學術兼職：