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王小兵，男，博士，副教授，碩士研究生導(dǎo)師，研究領(lǐng)域為天然活性成分研究與開發(fā)。

2001年畢業(yè)于漢中師范學(xué)院，獲化學(xué)教育專業(yè)學(xué)士學(xué)位；2005年畢業(yè)于陜西師范大學(xué)，獲有機化學(xué)專業(yè)碩士學(xué)位；2008年畢業(yè)于中國藥科大學(xué)，獲藥物化學(xué)專業(yè)博士學(xué)位。2008年7月留校天然藥物化學(xué)教研室工作，2011年6月晉升為副教授。2015年作為訪問學(xué)者，在The Scripps Research Institute的Jin-Quan Yu教授課題組從事有機合成中的碳氫活化和天然產(chǎn)物合成研究工作。現(xiàn)主持國家自然科學(xué)基金面上項目和江蘇省自然科學(xué)基金青年項目各一項，參與多項國家和省部級基金項目。

研究方向：

1.基于天然產(chǎn)物的合理藥物設(shè)計與研究；
2.天然產(chǎn)物結(jié)構(gòu)修飾與全合成；
3.天然產(chǎn)物生物轉(zhuǎn)化研究。

主持的基金項目：

1.國家自然科學(xué)基金面上項目，基于天然產(chǎn)物“優(yōu)勢結(jié)構(gòu)”和藥物“活性片段”具有均衡活性的多靶點阿爾茨海默病藥物分子研究，編號：81573313,2016~2019.
2.江蘇省自然科學(xué)基金青年項目，若干常見中草藥活性成分的酶促生物轉(zhuǎn)化研究，編號：BK20130664,2013~2016.

近三年主要論文：

1.Sai-Sai Xie, Xiaobing Wang, Neng Jiang, Wenying Yu, Kelvin D. G. Wang, Jin-Shuai Lan, Zhong-Rui Li, Ling-Yi Kong*. Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European Journal of Medicinal Chemistry, 2015, 95, 153-165.
 2.Neng Jiang, Xiao-Bing Wang, Zhong-Rui Li, Su-Yi Li, Sai-Sai Xie, Ming Huang, Ling-Yi Kong*. Design of a structural framework with potential use to develop balanced multifunctional agents against Alzheimer's disease. RSC Advances, 2015, 5, 14242-14255.
3.Jin-Shuai Lan, Sai-Sai Xie, Ming Huang, Ya-Jian Hu, Ling-Yi Kong*, Xiao-Bing Wang*. Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency. Medchemcomm, 2015, 6, 1293-1302.
4.Weisi Xiong, Xiaobing Wang, Lingyi Kong*. Design and application of a biphasic system that enhances productivity of Daucus carota-catalyzed asymmetric reduction. Biotechnology Letters, 2015, 37, 1703-1709.
5.Ming Huang, Sai-Sai Xie, Neng Jiang, Jin-Shuai Lan, Ling-Yi Kong, Xiao-Bing Wang*. Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 508-513.
6.Sai-Sai Xie1, Jin-Shuai Lan1, Xiao-Bing Wang, Neng Jiang, Ge Dong, Zhong-Rui Li, Kelvin D. G. Wang, Ping-Ping Guo, Ling-Yi Kong*. Multifunctional tacrine–trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. European Journal of Medicinal Chemistry, 2015, 93, 42-50.
7.Zhi-Min Wang, Sai-Sai Xie, Xue-Mei Li, Jia-Jia Wu, Xiao-Bing Wang*, Ling-Yi Kong*. Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease. RSC Advances, 2015, 5, 70395-70409.
8.Xiao-Bing Wang1, Chang-Shui Yang1, Chao Zhang, Jun Luo, Ming-Hua Yang, Jian-Guang Luo, Wen-Ying Yu, Ling-Yi Kong*. Ten new calyxins from Alpinia katsumadai: a systematically studies on the stereochemistry of calyxins. Tetrahedron, 2014, 70, 8714-8722.
9.Su-Yi Li, Xiao-Bing Wang, Neng Jiang, Ling-Yi Kong*. Synthesis of (E)-1,4-Enediones from α-halo ketones through a sodium sulfinate mediated reaction. European Journal of Organic Chemistry. 2014, 8035-8039.
10.Li Su-Yi, Jiang Neng, Xie Sai-Sai, Wang Kelvin D. G., Wang Xiao-Bing*, Kong Ling-Yi*. Design, synthesis and evaluation of novel tacrine rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease. Organic & Biomolecular Chemistry 2014, 12, 801-814.
11.He Ye, Wang Xiao-Bing, Fan Bo-Yi, Kong Ling-Yi. Honokiol trimers and dimers via biotransformation catalyzed by Momordica charantia peroxidase: Novel and potent alpha-glucosidase inhibitors. Bioorganic & Medicinal Chemistry 2014, 22, 762-771.
12.Li Su-Yi, Wang Xiao-Bing, Kong Ling-Yi. Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. European Journal of Medicinal Chemistry 2014, 71, 36-45.
13.Xu Zi-Chen, Wang Xiao-Bing, Yu Wen-Ying, Xie Sai-Sai, Li Su-Yi, Kong Ling-Yi. Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 2014, 24, 2368-2373.
14.Xie Sai-Sai, Wang Xiao-Bing*, Li Jiang-Yan, Yang Lei, Kong Ling-Yi*. Design, synthesis and evaluation of novel tacrine coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. European Journal of Medicinal Chemistry 2013, 64, 540-553.
15.Xie Sai-Sai, Wang Xiao-Bing*, Li Jiang-Yan, Kong Ling-Yi*. Design, Synthesis and Biological Evaluation of Novel 7-Mercaptocoumarin Derivatives as alpha(1)-Adrenoceptor Antagonists. Chemical & Pharmaceutical Bulletin 2013, 61, 16-24.
16.Wang Xiao-Bing1, Zhang Yao1, Wang Jun-Song, Gu Yu-Cheng, Kong Ling-Yi. Novel ring A rearranged isomers with gamma-lactone from the fruits of Aphanamixis grandifolia. Tetrahedron Letters 2013, 54, 6023-6028.
17.Li Su-Yi, Wang Xiao-Bing, Xie Sai-Sai, Jiang Neng, Wang Kelvin D. G., Yao He-Quan, Sun Hong-Bin, Kong Ling-Yi. Multifunctional tacrine flavonoid hybrids with cholinergic, beta-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 2013, 69, 632-646.
18.Li Ren-Shi, Wang Xiao-Bing, Hu Xiao-Jun, Kong Ling-Yi. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 2013, 23, 2636-2641.
19.Hu Xiao-Jun, Wang Xiao-Bing, Kong Ling-Yi. alpha-Glucosidase Inhibitors via Green Pathway: Biotransformation for Bicoumarins Catalyzed by Momordica charantia Peroxidase. Journal of Agricultural and Food Chemistry 2013, 61, 1501-1508.
20.Bao Feng-Zu, Wang Xiao-Bing, Kong Ling-Yi. Pyrrolidine catalyzed novel domino reaction for the synthesis of polysubstituted 4-oxocyclohexanecarbaldehyde derivatives. Tetrahedron Letters 2013, 54, 1405-1408.

聯(lián)系方式：

通訊地址：南京市鼓樓區(qū)童家巷24號
郵政編碼：210009
電子信箱：xbwang@cpu.edu.cn
辦公電話：025-83271402