中國藥科大學生命科學與技術學院導師信息介紹：姚文兵

導師信息來源：中國考研網 2015-02-09　

姚文兵教授，男，博士生導師,中國藥科大學副校長

主要經歷

1962年6月生，1983年畢業于中國藥科大學生物制藥專業，后獲碩士、博士學位。1990年研究生畢業后留校任教。

自留校任教以來，一直從事教學、科研和管理工作。現任中國藥科大學微生物與生化藥學教授（博士生導師）、中國藥科大學副校長。兼任國家食品藥品監督管理局藥品、保健食品評審委員，國家發改委藥品價格決策專家委員會委員，中國生物化學與分子生物學會工業化專業委員會委員，教育部高職高專藥品類專業教學指導委員會主任委員，教育部高等學校藥學專業教學指導分委員會秘書長，全國高等醫學教育學會副秘書長，全國高等醫學教育學會藥學教育研究會副理事長兼秘書長，《藥物生物技術》副主編，《藥學教育》常務副主編，《中國藥學年鑒》、《中國藥科大學學報》等雜志編委。

主要科研工作簡介

主要從事的研究領域

多肽、蛋白質類藥物的分子改構（包括基于基因密碼子擴展的分子改構）和定點修飾研究以及生物新藥的研制。

課題資助情況

在以上研究領域已主持完成了國家科技重大專項課題、國家863項目、國家自然科學基金項目、教育部重點項目、江蘇省重點項目等國家及省部級課題26項。目前正主持國家自然科學基金、國家科技重大專項課題、博士點基金、江蘇省科技創新與成果轉化專項等項目7項。

完成的主要科研工作及獲獎情況

長期從事多肽、蛋白質類藥物的分子改構（包括基于基因密碼子擴展的分子改構）和定點修飾研究以及生物新藥的研制，圍繞多肽和蛋白質藥物的分子改構及其在創新藥物中應用開展系列研究，1）建立了與國際前沿同步的非天然氨基酸定點改構技術體系； 2) 建立了多肽、蛋白質類藥物修飾技術平臺和質量評價體系， 3）開展長效多肽、蛋白質類創新藥物研究，完成了PEG—ED、PEG2—IFNcon 等長效蛋白質類藥物和長效多肽類藥物的臨床前研究。在該領域主持國家“重大新藥創制”科技重大專項、國家“863”項目、國家自然科學基金等國家級及省部級課題26項；帶領的科研團隊獲得江蘇省“青藍工程”科技創新團隊。近五年，獲授權發明專利10項，發表科研論文72篇， SCI論文37篇，出版著作5部。

榮獲國家級教學名師，入選教育部“新世紀優秀人才支持計劃”，江蘇省“333高層次人才培養工程”第二層次培養對象，江蘇省“六大人才高峰”，獲全國高校優秀青年教師獎（教育部霍英東教育基金會），江蘇省優秀教育工作者等榮譽稱號。為國家優秀教學團隊帶頭人，國家精品課程《藥學生物化學基礎》課程負責人，獲國家級教學成果獎一等獎3項、國家級教學成果獎二等獎1項，獲江蘇省教學成果獎特等獎2項、江蘇省教學成果獎一等獎2項。獲江蘇省科技進步三等獎2項。

研究生培養情況

已培養碩士研究生62名，博士研究生20名。

近期發表的代表性論文

1．Mingming Gao,Yue Tong,Hong Tian,Xiangdong GaoandWenbing Yao. Recombinant production of mGLP-1 by coupling of refolding and intein-mediated self-cleavage (CRIS). Appl Microbiol Biotechnol. DOI 10.1007/s00253-012-4163-4

2．Mingming Gao,Yuhao Jin,Yue Tong, Hong Tian,Xiangdong Gao,Wenbing Yao. A site-specific PEGylated analog of exendin-4 with improved pharmacokinetics and pharmacodynamics in vivo. Journal of Pharmacy and Pharmacology. doi: 10.1111/j.2042-7158.2012.01545.x

3．Hong Tian, Yuan Guo, Xiangdong Gao,Wenbing Yao. PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. Journal of Pharmacy and Pharmacology. DOI:10.1111/j.2042-7158.2012.01575.x

4．Wei Guo, Chen Luo, Chen Wang, Yue Zhu, Xin Wang, Xiangdong Gao, Wenbing Yao. Protection against Th17 Cells Differentiation by an Interleukin-23 Receptor Cytokine-Binding Homology Region. Plos One. 2012, 7(9): e45625

5．Mingming Gao , Yue Tong , Wen Li , Xiangdong Gao , Wenbing Yao. Improving the anti-diabetic activity of GLP-1 by fusion with globular adiponectin. Artificial Cells, Blood Substitutes, and Biotechnology. DOI: 10.3109/10731199.2012. 712042

6．Hai Chen, Yingfei Lu, Zhengzhi Fang, Jingxian Liu, Hong Tian, Xiangdong Gao and Wenbing Yao. High-level production of uricase containing keto functional groups for site-specific PEGylation. Biochemical Engineering Journal, 2011,58(59): 25-32

7．Zhengzhi Fang, Yaguang Liu, Jingxian Liu, Renhua Sun, Hai Chen, Xiangdong Gao, Wenbing Yao. Designing and engineering of a site-specific incorporation of a keto group in uricase. Chemical Biology & Drug Design, 2011, 78(3):353-360

8．Yuge Niu, Zhuohong Xie, JunJie Hao, WenBing Yao, Jin Yue, Liangli (Lucy) Yu. Preparation of succinylated derivatives of psyllium and their physicochemical and bile acid-binding properties. Food Chemistry, 2012,132: 1025–1032

9．Cao Jin, Meng Fang, Gao Xiangdong, Dong Hongxia, Yao Wenbing. Expression and Purification of a Natural N-Terminal Pre-ligand Assembly Domain of Tumor Necrosis Factor Receptor 1 (TNFR1 PLAD) and Preliminary Activity Determination. The Protein Journal, 2011, 30(4): 281-289

10． Yuge Niu, Hengyu Wang, Zhuohong Xie, Monica Whent, Xiangdong Gao, Xian Zhang, Shan Zou, Wenbing Yao, Liangli Yu. Structural Analysis and Bioactivity of a Polysaccharide from the Roots of Astragalus membranaceus (Fisch) Bge. var. mongolicus (Bge.) Hsiao. Food Chemistry, 2011, 128: 620–626

11． Jingjing Sun, Xiaoda Song, Hong Tian, Yuhao Jin, Xiangdong Gao, Wenbing Yao. Synthesis of a novel Histidine-Targeting poly(ethylene glycol) and modification of lysozyme. Journal of Applied Polymer Science, 2011, 119(4): 2183-2188

12． Ma Chen, Gao Mingming, Liu Wenchao, Zhu Jing, Tian Hong, Gao Xiangdong, Yao Wenbing. Intein-mediated Expression and Purification of an Analog of Glucagon-like Peptide-1 in Escherichia coli. Protein and Peptide Letters, 2010,17(10): 1245-1250

13． Mingming Gao, Chen Ma, Wenchao Liu, Jing Zhu, Hong Tian, Xiangdong Gao, Wenbing Yao. Production and purification of an analog of glucagon-like peptide-1 by auto-induction and on-column cleavage in Escherichia coli. World J Microbiol Biotechnol, 2010, 26(9): 1675–1682

14． Min Ren, Wei Yan, Wenbing Yao, Lei Jin, Xiangdong Gao. Enzymatic degradation products from a marine polysaccharide YCP with different immunological activity and binding affinity to macrophages, hydrolyzed by a-amylases from different origins. Biochimie, 2010,92:411-417

15． Wei Liu, Jing Xu, Pu Jing, Wenbing Yao, Xiangdong Gao, Liangli (Lucy) Yu. Preparation of a hydroxypropyl Ganoderma lucidum polysaccharide and its physicochemical properties. Food Chemistry, 2010, 122: 965–971

16． WeiLiu, HengyuWang, WenbingYao, XiangdongGao and Liangli (Lucy)Yu. Effects of Sulfation on the Physicochemical
and Functional Properties of a Water-Insoluble Polysaccharide Preparation from Ganoderma lucidum. J. Agric. Food Chem., 2010, 58 (6): 3336–3341

17． WeiLiu, ZhuohongXie, BoceZhang, QinWang, WenbingYao, XiangdongGao and Liangli (Lucy)Yu. Effects of Hydroxypropylation on the Functional Properties of Psyllium.J. Agric. Food Chem., 2010, 58 (3): 1615–1621

18． WeiLiu, BoceZhang, QinWang, ZhouhongXie, WenbingYao, XiangdongGao and Liangli (Lucy)Yu. Effects of Sulfation on the Physicochemical and Functional Properties of Psyllium. J. Agric. Food Chem., 2010, 58 (1): 172–179

19． Wei Liu, Hengyu Wang, Xiubing Pang, Wenbing Yao, Xiangdong Gao. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. International Journal of Biological Macromolecules,2010,46:451-457

20． Yue Tong, Kai Zhong, Hong Tian, Xiangdong Gao, Xiangyang Xu, Xiaojin Yin, Wenbing Yao. Characterization of a monoPEG20000-Endostar. International Journal of Biological Macromolecules,2010,46(3):331-336

21． MingmingGao, HongTian, ChenMa, XiangdongGao, WeiGuo and WenbingYao. Expression, Purification, and C-terminal Site-Specific PEGylation of Cysteine-Mutated Glucagon-Like Peptide-1. Applied Biochemistry and Biotechnology, 2010,162(1):155-165

22． Shan Zou, Xian Zhang, Wenbing Yao, Yuge Niu, Xiangdong Gao. Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L. Carbohydrate Polymers, 2010,80:1161-1167

23． Renhua Sun, Heng Zheng, Zhengzhi Fang and Wenbing Yao. Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-l-phenylalanine. Biochemical and Biophysical Research Communications, 2010, 391(1): 709-715

24． Jin Cao‌, Yu Du‌, Hong Tian‌, Xiangdong Gao‌, Wenbing Yao‌. Quantitative determination of pegylated consensus interferon in rhesus monkey serum using a competitive enzyme-linked immunosorbent assay. Immunopharmacol Immunotoxicol, 2009,31(4):543-549